Human Sera
Cayman Chemical UDPD-GlucosesodIum salt 100mg
A non-selectiveBadrenergic receptor blocker that acts on both B1 and B2 receptors
Cayman Chemical 13 E-DocosenoIc AcId 50mg
A semisynthetic echinocandin antifungal inhibits 13-b-D glucan synthase from several C albicans clinical isolates (IC50s 0 89-7 96 ng/ml for the wild-type enzyme) active against C albicans C parapsilosis C tropicalis and C guiillermondi (MICs 0 03-4 Ug/ml) and A fumigatus (MIC90 0 03 Ug/ml) increases survival and decreases the severity of pulmonary lesions in A fumigatus-infected neutropenic rabbits at 10 mg/kg
Cayman Chemical CID-2818500 100mg
An aldose reductase inhibitor that blocks the conversion of glucose to sorbitol (Kis 7 7 nM and 60 UM for aldose reductase 2 and 1 respectively) prevents diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats impairs the synthesis of PGF2a by human cultured preadipocytes
Cayman Chemical GamIthromycIn 100mg
A reagent used to detect singlet oxygen generation can be photobleached by singlet oxygen to its corresponding endoperoxide
Cayman Chemical PInostrobIn 50mg
A PPARY agonist activates PPARY in a reporter assay using CV-1 cells expressing murine PPARY2 from 0 1-1 M increases [3H]2-deoxyglucose transport in the presence and absence of insulin and increases glycogen synthesis in the presence of insulin in soleus muscle strips isolated from obese rats at 1 5 and 25 M
Cayman Chemical ToltrazurIl sulfon 100mg
An inhibitor of STAT3 binds to STAT3 (Kd 504 nM) and inhibits STAT3 binding to an IL-6R/gp130 peptide in a fluorescence polarization assay (IC50 4 1 UM) decreases viability and proliferation of STAT3-dependent NIH3T3/v-Src MDA-MB-231 PANC-1 DU145 and A549 cancer cells but not STAT3-independent NIH3T3 NIH3T3/vRas TE-71 and A2780S cancer cells at 10-30 UM reduces tumor growth and inhibits expression of the STAT3-dependent genes encoding c-Myc survivin Bcl-xL cyclin D1 and VEGF in MDA-MB-231 and A549 mouse xenograft models at 1 and 3 mg/kg
Cayman Chemical 5 N NhexamethylenAmIlorI 50mg
A mitochondria-targeted fluorescent probe AIE active abs/em 485/705 nm respectively can be used in live cells and in vivo
Cayman Chemical DGlucosamIn6phosphAThy 50mg
A synthetic GnRH peptide agonist that binds to GnRHR (Ki 0 3 nM in CHO cells expressing the human receptor) inhibits the growth of DU145 LNCaP and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s 62 1 73 4 98 1 and 67 7 M respectively) inhibits the growth of the TNBC HCC1806 and MDA-MB-231 cancer cell lines (EC50s 58 29 and 31 59 M respectively) stimulates FSH and LH release from primary rat pituitary cells at 50 nM decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats at 1 mg/kg per day
Cayman Chemical ValrocemIde 50mg
An analytical reference standard categorized as a tryptamine induces the HTR in mice intended for research and forensic applications
Cayman Chemical Apararenon 50mg
A fluorogenic substrate forBhexosaminidases is cleaved byBhexosaminidases to release the fluorescent moiety 4-U ex 320 and 360 nm at low (1 97-6 72) and high pH (7 12-10 3) respectively em 445 to 455 nm increasing as pH decreases has been used to quantifyBhexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease
Cayman Chemical Curcuma zdoara Grmacron 100mg
An anticancer agent inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cancer cells (IC50s 4 6 and 3 4 M respectively) inhibits S to G2 and G2/M to G1 cell cycle progression decreases tumor volume and increases survival in a Lewis lung carcinoma mouse model at 44 mg/kg decreases tumor volume in an HNC-3 head and neck cancer xenograft mouse model at 40 mg/kg exhibits reduced nephrotoxicity in rats compared with cisplatin